Technology acceptance is a widely acknowledged key player in explaining technology adoption. However, there is a notable knowledge gap concerning the impact of cultural factors on technology acceptance, especially in the medical sector. It is evident though that countries differ greatly regarding their technical proneness, development and usage habits what should have considerable impact on acceptance. This study compares the openness to accept medical technology in Germany, Poland and Turkey. 300 respondents (19-85 years, 56% women, 38% chronically ill) participated in a survey, in which the pros and cons for using medical technologies were examined as well as the underlying acceptance motives and utilization barriers. The effects of different cultures, but also of age, gender and health status were analyzed regarding their impact on acceptance patterns. Results reveal both, culturally insensitive as well culturally sensitive acceptance, with strong effects of gender and exercising frequency. Overall, the study corroborates the importance of cultural views on technology acceptance.